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1.0 Introduction

The IAG Fit-to-Fly Guidelines 2024/5 have been written by medical professionals within the IAG who have volunteered their time and knowledge.

These guidelines pertain to commercial air travel only.   

It is not intended as a training course in aviation medicine or repatriation.  This document does not cover the physical laws of altitude and flight.  

Although highly specialized in patients’ inhospital care, many physicians are not well versed in the pathophysiological impact of air travel.  IAG recommends engaging with specialists when there is a large discrepancy which may place the patients’ wellbeing at risk or prejudice the funder. 

Patients must be Individualised; multiple diagnoses, comorbidities and physical reserve need to be considered when deciding fitness-to-fly.  Medical professionals are urged to refer to multiple sections of this document when dealing with complicated cases.  

IAG Fit-to-Fly Guidelines 2024/5 are intended to assist medical professionals make evidence-based decisions when coordinating commercial flight/s for patients who have been acutely ill / injured.  The patient’s clinical state combined with these guidelines determines a delayed date of departure, seating position, need for in-flight oxygen and medical or non-medical escorts.    

The guidelines are based on evidence extracted from internationally published guidelines as well as journal articles dealing with aeromedical concepts, medical conditions and how these impact each other. 

2.0 Definitions
Term Definition 
  50m Walk Test (1) A patient can walk 50m at normal pace without developing subjective / objective cardiopulmonary distress.  Simple and valid test showing sufficient cardiopulmonary reserve for inflight conditions.  Assists when considering inflight supplemental O2.  May be performed as an inpatient / outpatient. 
Barometric pressure Also known as air pressure or atmospheric pressure.   
Hospital-Associated Deconditioning (2) Patient’s physical, mental, and psychological functioning may be reduced because of acute hospitalization.  Risk factors are the geriatric age group, life-threatening diagnoses, course of admission, social situation, and patients with pre-existing cognitive decline. 
Haemodynamically stable Vital signs are with normal limits, not subject to unexpected changes.  
Hypobaric hypoxia Environmental condition of low O2 concentration at high altitudes. 
Medical Escort Medical professional providing care during patient travel; typically providing a bed-to-bed service 
Non-medical Escort Lay person assisting patients with activities of daily living.  Typically, the patient has completed all treatment and has been discharged from hospital.  May be a family member / friend.  
Long haul flight Continuous flight longer than 4 hours. 
Stable patient (3) The patient’s medical condition is not expected to develop sudden deterioration and does not require frequent or intensive medical treatment. 
References
1.Tzani, P.  Pisi, G.  Aiello, M et al  Flying with Respiratory Disease.  Respiration 2010;80:161-170  Available from: DOI: 10.1159/000313425
2.Chen, Y.  Almirall-Sanchez, A.  Mockler, D. et al.  Hospital-associated deconditioning: Not only physical, but also cognitive.  Int J Geriatr Psychiatry.  2022;1-13  Available from:doi:10.1002/gps.5687
3.Vincent, J.  Cecconi. M. Saugel, B. Is this patient really “(un)stable”?  How to describe cardiovascular dynamic in critically ill patients.  Critical Care (2019) 23:272 Available from: http://doi.org/10.1186/s13054-019-2551-1
3.0 Medical Clearance

Medical clearance from the intended airline will need to be obtained from that medical department.   

Application will need to be submitted in writing on the respective MEDIF form at least 72 hours before departure.  The airline’s medical department may request additional medical information other than stated on the MEDIF. 

Application for stretcher transport may take a couple weeks’ lead time.  

Compulsory Applications 

  • Stretcher transport 
  • Medical escort 
  • Medical equipment: incubator, upper airway suction, nebuliser, medications 
  • Airport / inflight / layover oxygen 
  • Airport clinic admission during layovers 
  • Medical condition / recovery from such which may be adversely affected by the flight environment 
  • Special seating arrangement: bulkhead, additional leg room, infant cot.  Patients may not be seated at emergency exits. 
  • Patient’s condition may be a hazard / cause discomfort to other passengers  
  • Patient who is incapable of performing activities of day living 
  • Non-medical escort 

General criteria for patient acceptance

  • Good prognosis for the trip
  • Patient is able to remain seated upright for at least 45 minutes unaided
  • Clinical condition will not be offensive to other passengers – for example odour
  • Patient is not a danger to themselves nor the aircraft / other passengers
  • Toileting is managed appropriately and discretely, no bed pans / urinary bottles are permitted
  • Medical equipment must be battery operated with 150% battery capacity

The airline and the pilot of the aircraft hold the ultimate decision for accepting or rejecting the application.

4.0 General Recommendations

These guidelines are not intended to cover flight physiology.  Rather, they apply flight physiology to the pathophysiological process of diseases and the patient’s course of management.

Individualise patient’s prophylactic anticoagulation and graded compression stockings for DVT prevention in high-risk patients. 

At cruising altitude, the cabin is a hypobaric hypoxic environment.  

Inflight, passengers will be breathing the equivalent of FiO2 0.15 at sea level. 

Hospital-Associated-Decompensation (HAD) may occur at any age.  Patient diagnosis, length of stay and course of admission all contribute to HAD.  Physical, psychological, and cognitive functioning may decline. Recovery to baseline functioning may take months. Consider lie-flat seating, and non-medical escort. (2) 

Patients requiring supplemental O2 at altitude require approximately 1-2 L/min additional continuous flow to maintain ground respiratory status. 

5.0 Medical Escort Capabilities

IAG recommends selecting a Service Provider with international accreditation. 

  1. European Aero-Medical Institute (EURAMI) 
  2. Commission on Accreditation of Medical Transport Systems (CAMTS)  
  3. National Accreditation Alliance of Medical Transport Applications (NAAMTA Global)   
5.1 Levels of Care

A commercial medical escort transport mission is defined as the transport of a patient whose condition warrants monitoring and minimal medical attention on a commercial aircraft.  Transfer may include multiple flights including airport layovers. 

Patients’ level of care should be individualised according to their clinical status, medical needs and HAD. 

The medical attendant must be certified to practice independently with ability to attend to the patient should they complicate.  All administration of medication and procedures should be well within their scope of practice.

Commercial Airline Medical Escort Standard Care

A stable patient requiring basic medical care for the duration of the transfer.  One medical attendant is appropriate.

Commercial Airline Medical Escort Advanced Care

  • Stable patients who require nursing care on the transfer such as (but not limited to):
  • O2 supplementation
  • Drainage bags – urinary catheter, surgical drains, NG tube bags
  • Dressing changes of open wounds
  • Medication administration / supervision of self-administration
  • Dietary supervision
  • Potential cardiac deterioration requiring emergency medical care
  • Potential diabetic complications requiring emergency medical care
  • Potential respiratory complications requiring emergency medical care.
  • At least one medical attendant is permitted.

Commercial Airline Medical Escort Paediatrics

  • Transfer of neonates by commercial medical escort is not recommended.
  • Stable paediatric patients requiring nursing care such as (but not limited to):
  • O2 supplementation
  • Drainage bags – urinary catheter, surgical drains, NG tube bags
  • Dressing changes of open wounds
  • Medication administration
  • Potential cardiac deterioration requiring emergency medical care
  • Potential respiratory complications requiring emergency medical care
  • Medical personnel with additional qualifications in paediatric intensive care are recommended.

Commercial Medical Escort Stretcher Transport

  • Stable patients with limited mobility.
  • Patients who are unable to obtain or maintain an upright position for longer than 45 minutes.
  • Patient examples are (but not limited to):
  • Paralysis
  • Neurological deficit post stroke
  • Back injuries / recent surgery
  • A urinary catheter is recommended.
  • Bowel prep is recommended no closer than 24 hours prior to departure.
  • Two medical escorts are recommended.

Advanced Life Support (ALS) or Registered Nurse

  • Scope of practice for a Registered Nurse, Critical Care Attendant (Paramedic) or Respiratory Therapist 
  • Stable patient 
  • Medical care including (but not limited to):
  • Basic airway management 
  • Supplemental oxygen  
  • Blood glucose control 
  • Fluid drainage bags 
  • Dressing changes  
  • Administration of oral / intermuscular medication 
  • Dietary supervision 

Medical Doctors as Escorts

  • Medical doctor escorts are not required in most cases.
  • Consider an AA should the patient require complex care.
5.2 References

CAMTS Medical Escort Accreditation Standards 7th Edition (2023) Commission on Accreditation of Medica Transport Systems.  Available from https://www.camts.org/standards/

6.0 The Cardio Vascular System
  • Consult other organ systems for patients with multiple comorbidities. 
  • Consider the longest delay for a safe departure for patients following a complicated course of illness. 
6.1 Physiological Considerations Relevant to the Cardiovascular System
  • At cruising altitude, the cabin is a hypobaric hypoxic environment. 
  • Passengers will be breathing the equivalent of FiO2 0,15 at sea level. 
  • Heart rate, respiratory rate and blood pressure will increase as a compensatory measure to hypobaric hypoxia. (3) 
  • Increased heart rate with greater myocardial contraction results in an increased cardiac output, leading to higher O2 demand.  O2 demand may outstrip oxygen supply. (3) 
  • A Hb < 4,34 mmol/L (7 g/dL), cardiac output may increase in response to lower O2 carrying capacity.  A Hb 4,34 – 10 mmol/L (7 – 10g/dL) should be targeted and individualised according to patient pathology and cardiopulmonary reserve. (4,5,17) 
  • Blood pressure may increase with acceleration and deceleration forces on take-off and landing respectively. (3) 
  • Noise and vibration may increase systolic and diastolic blood pressure. (3) 
  • Hypobaric hypoxia may increase the frequency of PVC’s.  Prolonged mild to moderate hypoxia may cause sustained PVCs with possible degradation into clinically significant ventricular arrythmias. (6) 
  • The volume of intrathoracic free air post thoracic surgery increases at altitude.  Respiratory and cardiac function may be adversely affected by the greater volume. (1) 
  • The 50m Walk Test is a simple and validated test to demonstrate cardiopulmonary reserve (1).  Should the patient not be able to complete the entire 50m without stopping, then they are not FTF independently.    
  • Patients’ cardiopulmonary reserve may be adversely affected by HAD. 
  • Rupture of arterial aneurysms at altitude has not been proven in the clinical setting.  In-flight aortic aneurysm rupture has not been reported in the literature. (8) 
  • Hypobaric hypoxia may influence tissue oxygenation in peripheral vascular diseases. 
7.0 The Respiratory System

Consult other organ systems for patients with multiple comorbidities. 

Consider the longest delay for a safe departure for patients following a complicated course of illness.

7.1 Physiological Considerations Relevant to the Respiratory System 

Generating a higher Minute Volume (MV) is the physiological response to hypobaric hypoxia. Creating a greater Tidal Volume (TV) contributes more than a higher Respiratory Rate (RR) in this compensation. (4)

Cardiac compensation to hypoxia causes pulmonary vasoconstriction, blood flow is diverted to the apexes. (4) This generates a ventilation-perfusion (V/Q) mismatch.  Masses or diseases located in the apexes, will heighten the mismatch, causing early respiratory compromise. Other diseases affected by V/Q mismatch are Chronic Obstructive Pulmonary Disease (COPD), pulmonary embolism (PE), pulmonary fibrosis, cystic lung disease, pulmonary lobe resection. (4)

Pulmonary vasoconstriction may cause clinically significant increases in pulmonary vascular pressure. (1) 

Hospital-Associated-Deconditioning (HAD) will cause respiratory distress due to wasted respiratory musculature. (4)

Patients with neuromuscular disease / chest wall disease will tire quickly with the higher respiratory workload.

An arterial blood gas measurement for chronic lung disease patients of PaO2 < 67 mmHg on the ground, can be expected to drop to PaO2 < 50 mmHg in-flight. (4)

At cruising altitude, free air in the thoracic cavity increases approximately 30%. (4)

Cabin humidity is approximately 10%. Dry air may lead to airway irritation, and regression of symptoms in particular diseases.

Respiratory conditions can negatively impact cardiac functioning, special consideration should be given to patients with cardiopulmonary diseases. (1)

Respiratory decompensation can be accelerated by multiple comorbidities.

7.2 Assessment of Cardiopulmonary Reserve

The Hypoxic Challenge Test is the gold standard to predicting hypoxaemia in-flight, but this test is not widely available. (1)  The patient is exposed to FiO2 0.15 for 20 minutes.  At this point, an ABG is taken.  If the Pa O2 > 50mmHg and SpO2 > 85%, then the patient may not require supplemental O2 at altitude. 

The 50m Walk-Test is a reliable and easy test to run.  The patient walks 50 m at a brisk pace, if the patient can complete the 50 m without stopping and has not desaturated SpO2 < 85%, then they may not require supplemental O2 at altitude. (1, 2, 6).  Alternatively, the patient can climb 12 stairs.

The 6-Minute-Walk-Test is more accurate than the 50m Walk-Test to predict in-flight O2 desaturations. (1,2) The patient may start the walk is SpO2 > 95% at rest.  They attempt to walk for 6 minutes at their own pace, if the SpO2 remains >84%, the patient may not require supplemental O2 at altitude. (1, 2)

Resting SpO2 at sea level does not reliably predict respiratory decompensation in the cabin environment in patients with respiratory disease/s. (1,3,6)

FEV1 does not reliably predict respiratory decompensation in the cabin environment in patients with respiratory disease/s. (1,6)

Predictive equations estimating the degree of desaturation in-flight are not reliable. (1,3)

8.0 Recreational Diving and Decompression Illness
  • These guidelines refer to recreational diving only.
  • All information and considerations for FTF are taken directly from the DAN Guidelines.
  • Other documents published by DAN have been considered.
  • Important resources:
  • DAN Health and Medicine https://dan.org/health-medicine/
  • Undersea and Hyperbaric Medical Society Chamber Directory https://www.uhms.org/resources/other-links/chamber-directory.html
  • Consider and combine guidelines relevant to patient comorbidities.
  • Consider the longest delay for safe departure in divers with complications.
9.0 Recommended Medical Equipment

10.0 Abbreviations
Abbreviation 
Greater than
Less than
AAAir Ambulance
ABGArterial Blood Gas
BPBlood Pressure
DANDivers Alert Network
CABGCoronary Artery Bypass Graft
CNCranial Nerve
COADChronic Obstruction Airways Disease
COPDChronic Obstructive Pulmonary Disease
CSFCerebrospinal Fluid
CXRChest X-ray
DVTDeep Vein Thrombosis
ECGElectrocardiogram
FEV1Forced Expiratory Volume exhaled within the first second
FTFFit-to-Fly
HADHospital-Associated Deconditioning
HbHemoglobin
HRHeart Rate
INRInternational Normalized Ratio
LMWHLow Molecular Weight Heparin
LRTILower Respiratory Tract Infection
LVLeft Ventricle
LVEFLeft Ventricular Ejection Fraction
MVMinute Volume
NOACNon-vitamin K oral antagonist anticoagulant
NSTEMINon-ST-Elevation Myocardial Infarction
PaO2Partial Pressure of Oxygen
PAUPatient Assist Unit
PDA           Patent Ductus Arteriosus
PFOPatent Foramen Ovale
PEPulmonary Embolism
O2Oxygen
ROSCReturn of Spontaneous Circulation
RRRespiratory Rate
RVRight Ventricle
Sats / SpO2Oxygen saturation
STEMIST-Elevation Myocardial Infarction
TVTidal Volume
VSDVentricular Septal Defect
  
WCOBWheelchair assistance on board aircraft Patient unable to walk; consider stretcher
WCHCWheelchair assistance to aircraft seat Patient unable to walk; consider stretcher
WCHSWheelchair assistance to aircraft door Patient unable to climb stairs
WCHRWheelchair assistance to boarding ramp Patients able to climb stairs